부산대학교 도서관

This study aimed to investigate the effects of aqueous extract of Pelodiscis Carapax (PCE) in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) mice. PCE (200 mg/kg) was orally administered to C57BL/6 mice for 2 weeks. After MIA injection (75 mg/mL), we performed a behavior test (open field test, rotarod test) followed by micro-computed tomography, histopathological analysis, and real-time quantitative PCR analysis on knee joint tissues. PCE treatment improved general gait locomotor activity, joint morphological features, and histopathological features compared to the MIA-induced mice. In addition, it confirmed that the mRNA expression levels of tissue inhibitor of metalloproteinases (TIMP)-1 in the joint tissues were increased in the PCE-treated group. Our result revealed that PCE treatment phenotypically improved OA symptoms.