학술논문
Overcoming Preclinical Safety Obstacles to Discover (S)- N-((1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H-pyrazolo[5,1- b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
Document Type
Article
Author
McBride, C.; Trzoss, L.; Povero, D.; Lazic, M.; Ambrus-Aikelin, G.; Santini, A.; Pranadinata, R.; Bain, G.; Stansfield, R.; Stafford, J.A.; Veal, J.; Takahashi, R.; Ly, J.; Chen, S.; Liu, L.; Nespi, M.; Blake, R.; Katewa, A.; Kleinheinz, T.; Sujatha-Bhaskar, S.; Ramamoorthi, N.; Sims, J.; McKenzie, B.; Chen, M.; Ultsch, M.; Johnson, M.; Murray, J.; Ciferri, C.; Staben, S.T.; Townsend, M.J.; Stivala, C.E.
Source
In: Journal of Medicinal Chemistry . (Journal of Medicinal Chemistry, 10 November 2022, 65(21):14721-14739)
Subject
Language
English
ISSN
15204804
00222623
00222623