학술논문
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells
Document Type
Article
Author
Henry, J.R.; Peng, S.-B.; Zhang, X.; Zhang, Y.; Kays, L.; Hipskind, P.A.; Wrobleski, A.D.; Lobb, K.L.; Clay, J.M.; Cohen, J.D.; Walgren, J.L.; McCann, D.; Patel, P.; Clawson, D.K.; Guo, S.; Manglicmot, D.; Groshong, C.; Logan, C.; Starling, J.J.; Kaufman, M.D.; Ahn, Y.M.; Caldwell, T.M.; Vogeti, L.; Telikepalli, H.; Lu, W.-P.; Hood, M.M.; Rutkoski, T.J.; Smith, B.D.; Vogeti, S.; Miller, D.; Wise, S.C.; Flynn, D.L.; Chun, L.
Source
In: Journal of Medicinal Chemistry . (Journal of Medicinal Chemistry, 28 May 2015, 58(10):4165-4179)
Subject
Language
English
ISSN
15204804
00222623
00222623