학술논문
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Document Type
Article
Author
Stepan, A.F.; Claffey, M.M.; Reese, M.R.; Balan, G.; Barreiro, G.; Boscoe, B.P.; Chenard, L.K.; Coffman, K.J.; Drozda, S.E.; Ghosh, S.; Hou, X.; Karki, K.; O'Neil, S.; Sakurada, I.; Parikh, V.; Tuttle, J.B.; Verhoest, P.R.; Walker, D.P.; Won, A.; Wright, A.S.; Zhang, L.; Moen, M.A.; Trapa, P.; Shaffer, C.L.; Bohanon, M.J.; Smith, D.L.; Zaleska, M.M.; Dunetz, J.R.; Lazzaro, J.T.; Barricklow, J.; Cianfrogna, J.; Miller, E.L.; Mancuso, J.Y.; Cappon, G.D.; Houle, C.; Marcek, J.M.; Whritenour, J.; Chen, L.; Skaddan, M.; Zasadny, K.
Source
In: Journal of Medicinal Chemistry . (Journal of Medicinal Chemistry, 28 September 2017, 60(18):7764-7780)
Subject
Language
English
ISSN
15204804
00222623
00222623