학술논문
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Document Type
Article
Author
Lee, K.L.; Curran, K.J.; Dehnhardt, C.M.; Gavrin, L.K.; Goldberg, J.A.; Hepworth, D.; Lee, A.; Lovering, F.E.; Lowe, M.D.; Mathias, J.P.; Papaioannou, N.; Patny, A.; Saiah, E.; Strohbach, J.W.; Thomason, J.R.; Trzupek, J.D.; Vargas, R.; Zapf, C.W.; Bree, A.G.; Dower, K.; Hegen, M.; Kilty, I.C.; Lin, L.-L.; Murphy, E.A.; Rao, V.R.; Shen, M.W.H.; Shin, J.H.; Symanowicz, P.T.; Brodfuehrer, J.I.; Boscoe, B.P.; Chang, J.S.; Choi, C.; Chung, S.; Drozda, S.E.; Han, S.; Samardjiev, I.J.; Samas, B.M.; Soutter, H.H.; Vincent, F.; Wright, S.W.; Ambler, C.M.; Frisbie, R.K.; Anderson, D.R.; Day, J.E.; Hope, H.R.; Kamtekar, S.; Pierce, B.S.; Morgan, H.M.; Yan, J.
Source
In: Journal of Medicinal Chemistry . (Journal of Medicinal Chemistry, 13 July 2017, 60(13):5521-5542)
Subject
Language
English
ISSN
15204804
00222623
00222623