학술논문
Fluorescent hydrogel fibers for long-term in vivo glucose monitoring
Document Type
Conference
Author
Source
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International. :2140-2143 Jun, 2011
Subject
Language
ISSN
2159-547X
2164-1641
2164-1641
Abstract
Fluorescence-based implantable glucose sensors can provide continuous glucose monitoring (CGM) with wireless transdermal transmission and long-lasting activity in vivo. Here, we present a long-term in vivo glucose monitoring method using glucose-responsive fluorescent hydrogel fibers. The fiber structure enables the sensor to remain at an implantation site for a long period and be removed from the implantation site after use. We found that the polyethylene glycol (PEG)-bonded polyacrylamide (PAAm) hydrogel fibers reduced inflammation, transdermally glowed and continuously responded to blood glucose concentration changes after 2.5 months, showing their potential application for long-term in vivo continuous glucose monitoring.