학술논문
CryoRL: Reinforcement Learning Enables Efficient Cryo-EM Data Collection
Document Type
Conference
Author
Source
2024 IEEE/CVF Winter Conference on Applications of Computer Vision (WACV) WACV Applications of Computer Vision (WACV), 2024 IEEE/CVF Winter Conference on. :7877-7887 Jan, 2024
Subject
Language
ISSN
2642-9381
Abstract
Single-particle cryo-electron microscopy (cryo-EM) has become one of the mainstream structural biology techniques because of its ability to determine high-resolution structures of dynamic bio-molecules. However, cryo-EM data acquisition remains expensive and labor-intensive, requiring substantial expertise. Structural biologists need a more efficient and objective method to collect the best data in a limited time frame. We formulate the cryo-EM data collection task as an optimization problem in this work. The goal is to maximize the total number of good images taken within a specified period. We show that reinforcement learning offers an effective way to plan cryo-EM data collection, successfully navigating heterogenous cryo-EM grids. The approach we developed, cryoRL, demonstrates better performance than average users for data collection under similar settings.