학술논문

Using Machine Learning to Identify Organ System Specific Limitations to Exercise via Cardiopulmonary Exercise Testing
Document Type
Periodical
Source
IEEE Journal of Biomedical and Health Informatics IEEE J. Biomed. Health Inform. Biomedical and Health Informatics, IEEE Journal of. 26(8):4228-4237 Aug, 2022
Subject
Bioengineering
Communication, Networking and Broadcast Technologies
Components, Circuits, Devices and Systems
Computing and Processing
Signal Processing and Analysis
Lung
Heart rate
Testing
Physiology
Data visualization
Bioinformatics
Voltage-controlled oscillators
Accuracy
cardiopulmonary exercise testing (CPET)
exercise limitation
machine learning
interpretability
Language
ISSN
2168-2194
2168-2208
Abstract
Cardiopulmonary Exer cise Testing (CPET) is a unique physiologic medical test used to evaluate human response to progressive maximal exercise stress. Depending on the degree and type of deviation from the normal physiologic response, CPET can help identify a patient's specific limitations to exercise to guide clinical care without the need for other expensive and invasive diagnostic tests. However, given the amount and complexity of data obtained from CPET, interpretation and visualization of test results is challenging. CPET data currently require dedicated training and significant experience for proper clinician interpretation. To make CPET more accessible to clinicians, we investigated a simplified data interpretation and visualization tool using machine learning algorithms. The visualization shows three types of limitations (cardiac, pulmonary and others); values are defined based on the results of three independent random forest classifiers. To display the models’ scores and make them interpretable to the clinicians, an interactive dashboard with the scores and interpretability plots was developed. This machine learning platform has the potential to augment existing diagnostic procedures and provide a tool to make CPET more accessible to clinicians.