학술논문
Designing Oxygen Microbubbles for Treating Tumor Hypoxia
Document Type
Conference
Author
Source
2019 IEEE International Ultrasonics Symposium (IUS) Ultrasonics Symposium (IUS), 2019 IEEE International. :1338-1341 Oct, 2019
Subject
Language
ISSN
1948-5727
Abstract
Here we report on an oxygen microbubble that has increased circulation and contrast persistence to treat tumor hypoxia during X-ray therapy. In recent work, oxygen microbubbles injected directly into tumors were shown to oxygenate hypoxic tumors and improve radiation therapy [1]. Here, we investigate oxygen microbubbles designed for intravenous, rather than intra-tumoral, injection. Oxygen microbubbles were designed with two phospholipid shell compositions, DSPC (C18:0) and DBPC (C22:0). DBPC microbubbles showed a significant increase in ultrasound contrast persistence in vivo in the mouse kidney, and this composition may be ideal for an intravascular microbubble injection to treat tumor hypoxia in radiation oncology.