학술논문

Experimental Validation of a Preclinical SPECT/MR Insert
Document Type
Conference
Source
2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2017 IEEE. :1-3 Oct, 2017
Subject
Bioengineering
Components, Circuits, Devices and Systems
Computing and Processing
Nuclear Engineering
Photonics and Electrooptics
Single photon emission computed tomography
Image reconstruction
Energy resolution
Collimators
Magnetic resonance imaging
Language
ISSN
2577-0829
Abstract
The experimental characterization of a SiPM-based 10-module SPECT gamma imager suitable for insertion and operation inside unmodified MR scanners for simultaneous (and potentially multi-tracer) preclinical imaging is presented. The design challenges, here fulfilled, such as compactness while granting proper cooling, mutual compatibility and resilience to high (3-7 T) magnetic fields inside the bore, suitable energetic (better than 14% at 140 keV) and spatial resolution (better than 1 mm) are discussed. The carefully optimized detection module, featuring a $5\times5 cm^{2}$ CsI(Tl) scintillator coupled to arrays of SiPM conditioned by a 36-channel ASIC, and the digital daisy chain infrastructure are the basis for the realization of a larger (20-module ring) clinical insert. Moreover, planar image reconstruction based on advanced statistical approaches such as maximum likelihood and iteratively estimated light response function is reported.