학술논문

Exploring the Robustness of the Parsimonious Reconciliation Method in Host-Symbiont Cophylogeny
Document Type
Periodical
Source
IEEE/ACM Transactions on Computational Biology and Bioinformatics IEEE/ACM Trans. Comput. Biol. and Bioinf. Computational Biology and Bioinformatics, IEEE/ACM Transactions on. 16(3):738-748 Jun, 2019
Subject
Bioengineering
Computing and Processing
Vegetation
Robustness
Phylogeny
Perturbation methods
Symbiosis
Switches
Cophylogeny
parsimony
event-based methods
robustness
measure for tree reconciliation comparison
Language
ISSN
1545-5963
1557-9964
2374-0043
Abstract
The aim of this paper is to explore the robustness of the parsimonious host-symbiont tree reconciliation method under editing or small perturbations of the input. The editing involves making different choices of unique symbiont mapping to a host in the case where multiple associations exist. This is made necessary by the fact that the tree reconciliation model is currently unable to handle such associations. The analysis performed could however also address the problem of errors. The perturbations are re-rootings of the symbiont tree to deal with a possibly wrong placement of the root specially in the case of fast-evolving species. In order to do this robustness analysis, we introduce a simulation scheme specifically designed for the host-symbiont cophylogeny context, as well as a measure to compare sets of tree reconciliations, both of which are of interest by themselves.