학술논문

Domain Adaptive Multiple Instance Learning for Instance-Level Prediction of Pathological Images
Document Type
Conference
Source
2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI) Biomedical Imaging (ISBI), 2023 IEEE 20th International Symposium on. :1-5 Apr, 2023
Subject
Bioengineering
Computing and Processing
Photonics and Electrooptics
Signal Processing and Analysis
Pathology
Costs
Image analysis
Annotations
Pipelines
Machine learning
Task analysis
Multiple Instance Learning
Domain Adaptation
Language
ISSN
1945-8452
Abstract
Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it difficult to apply machine learning techniques. One way to improve the performance of identifying abnormalities while keeping the annotation cost low is to use only labels for each slide, or to use information from another dataset that has already been labeled. However, such weak supervisory information often does not provide sufficient performance. In this paper, we proposed a new task setting to improve the classification performance of the target dataset without increasing annotation costs. And to solve this problem, we propose a pipeline that uses multiple instance learning (MIL) and domain adaptation (DA) methods. Furthermore, in order to combine the supervisory information of both methods effectively, we propose a method to create pseudo-labels with high confidence. We conducted experiments on the pathological image dataset we created for this study and showed that the proposed method significantly improves the classification performance compared to existing methods.