학술논문
Survival of adhering cortical neurons on polyethylenimine micropatterns
Document Type
Conference
Author
Source
2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in medicine and biology Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE. 1:749-752 vol.1 2001
Subject
Language
ISSN
1094-687X
Abstract
The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with diameters of 25, 50, 100 and 150 /spl mu/m and inter-microwell distances of 15, 30, 60 and 90 /spl mu/m, were etched in a neuron-repellent fluorocarbon (FC)-layer and coated with neuron-adhesive polyethylenimine (PEI). Results showed that the survival of neural tissue was geometry-independent after 1, 4 and 8 days but was favored on 150 /spl mu/m wells after 15 days.