학술논문

CANARY sensor for rapid, sensitive identification of pathogens
Document Type
Conference
Author
Source
2006 Bio Micro and Nanosystems Conference Bio Micro and Nanosystems Conference, 2006. BMN '06. :34-34 Jan, 2006
Subject
Bioengineering
Components, Circuits, Devices and Systems
Pathogens
Laboratories
Risk analysis
Genetic engineering
White blood cells
Microorganisms
Viruses (medical)
Medical diagnosis
Biomedical monitoring
Language
Abstract
We have developed a new type of sensor, dubbed CANARY (Cellular Analysis and Notification of Antigen Risks and Yields), that is able to identify pathogens in a very rapid, sensitive, and specific manner. The sensor uses genetically engineered white blood cells that emit light within seconds after being exposed to particular pathogens of interest. We have produced cells to identify a variety of bacteria and viruses, including anthrax, smallpox, plague, E. coli, and foot-and-mouth virus, and we have shown that the cells can detect fewer than 50 pathogen particles. Because of its speed and sensitivity, CANARY has the potential to revolutionize biowarfare defense, medical diagnostics, food- and water-quality monitoring, and other applications