학술논문

Development of an integrated microelectrode/microelectronic device for brain implantable neuroengineering applications
Document Type
Conference
Source
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and biology Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE. 2:4053-4056 2004
Subject
Bioengineering
Microelectrodes
Microelectronics
Neural engineering
Brain
Silicon
CMOS integrated circuits
Hybrid integrated circuits
Preamplifiers
Bonding
Integrated circuit measurements
Neuroprosthesis
brain computer interface
low-noise preamplifier
integrated neural probe array
Language
Abstract
An ultra-low power analog CMOS chip and a silicon based microelectrode array have been fully integrated to a microminiaturized "neuroport" for brain implantable neuroengineering applications. The CMOS IC included preamplifier and multiplexing circuitry, and a hybrid flip-chip bonding technique was developed to fabricate a functional , encapsulated microminiaturized neuroprobe device. As a proof-of-concept demonstration, we have measured local field potentials from thalamocortical brain slices of rats, suggesting that the new neuroport can form a prime platform for the development of a microminiaturized neural interface to the brain in a single implantable unit.