학술논문

Integrated Optoelectronic Device for Detection of Fluorescent Molecules
Document Type
Periodical
Source
IEEE Transactions on Biomedical Circuits and Systems IEEE Trans. Biomed. Circuits Syst. Biomedical Circuits and Systems, IEEE Transactions on. 12(6):1337-1344 Dec, 2018
Subject
Bioengineering
Components, Circuits, Devices and Systems
Fluorescence
System-on-chip
Light emitting diodes
Biomedical optical imaging
Photosensors
Absorption
DNA
Amorphous silicon photosensors
DNA detection
fluorescence
interferential filters
ruthenium complexes detection
Language
ISSN
1932-4545
1940-9990
Abstract
This paper presents the development of a compact optoelectronic device suitable for on-chip detection of fluorescent molecules. In order to obtain a highly integrated device, a long-pass multi-dielectric filter has been integrated with thin-film amorphous silicon photosensors on a single glass substrate. Filter rejects the excitation light, allowing the reduction of the distance between the source and the fluorescent site and avoiding the use of external optical component. The compatibility of the technological processes determined the materials and the temporal sequence of the device fabrication. The developed device has been designed for the fluorescence detection of ruthenium complex based molecules and tested, as a proof of concept, for the detection of double-stranded DNA down to 0.5 ng. Results demonstrate the correct operation of the integrated system in both rejecting the excitation light and in detecting the fluorescent signal, demonstrating the suitability of this optoelectronic platform in practical biomedical applications.