학술논문

An in silico trials platform for the evaluation of stent design effect in post-implantation outcomes
Document Type
Conference
Source
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) Engineering in Medicine & Biology Society (EMBC), 2022 44th Annual International Conference of the IEEE. :4970-4973 Jul, 2022
Subject
Bioengineering
Geometry
Drugs
Technological innovation
Biological system modeling
Pipelines
Europe
Atherosclerosis
Language
ISSN
2694-0604
Abstract
Bioresorbable Vascular Scaffolds (BVS), developed to allow drug deliver and mechanical support, followed by complete resorption, have revolutionized atherosclerosis treatment. InSilc is a Cloud platform for in silico clinical trials (ISCT) used in the design, development and evaluation pipeline of stents. The platform integrates beyond the state-of-the-art multi-disciplinary and multiscale models, which predict the scaffold's performance in the short/acute and medium/long term. In this study, a use case scenario of two Bioabsorbable Vascular Stents (BVSs) implanted in the same arterial anatomy is presented, allowing the whole InSilc in silico pipeline to be applied and predict how the different aspects of this intervention affect the success of stenting process.