학술논문
A CMOS Electrochemical Biochip With 32 $\times$ 32 Three-Electrode Voltammetry Pixels
Document Type
Periodical
Author
Source
IEEE Journal of Solid-State Circuits IEEE J. Solid-State Circuits Solid-State Circuits, IEEE Journal of. 54(11):2980-2990 Nov, 2019
Subject
Language
ISSN
0018-9200
1558-173X
1558-173X
Abstract
A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 $\times $ 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 $\mu \text{m}\,\times 100\,\,\mu \text{m}$ pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel $\Sigma \Delta $ current detection circuitry with 280 fA rms input-referred noise (0.1–20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.