학술논문

A Portable CMOS-Based Spin Resonance System for High-Resolution Spectroscopy and Imaging
Document Type
Periodical
Source
IEEE Journal of Solid-State Circuits IEEE J. Solid-State Circuits Solid-State Circuits, IEEE Journal of. 58(7):1838-1849 Jul, 2023
Subject
Components, Circuits, Devices and Systems
Engineered Materials, Dielectrics and Plasmas
Computing and Processing
Nuclear magnetic resonance
Magnetic resonance imaging
Radio frequency
Integrated circuits
Spectroscopy
Transceivers
Permanent magnets
Bioelectronics
CMOS-integrated circuit (IC)
magnetic resonance imaging (MRI)
nuclear magnetic resonance (NMR)
radio frequency (RF) IC
Language
ISSN
0018-9200
1558-173X
Abstract
Nuclear magnetic resonance (NMR) is a paramount analytical tool for chemistry, biology, medicine, and geology, and has a fundamental importance in physics. The recent years have seen a wealth of efforts to miniaturize NMR systems by combining permanent magnets and CMOS radio frequency (RF)-integrated circuits (ICs) to make the benefit of NMR more broadly available beyond dedicated facilities, which have resulted in systems capable of NMR relaxometry first, and later NMR spectroscopy, the two key NMR modalities. Here we report a small NMR system comprising a digitally assisted CMOS RF transceiver IC and a 0.51-T permanent magnet, which not only enhances spectroscopy and relaxometry performance but also includes magnetic resonance imaging (MRI), a powerful variant of relaxometry. The system achieves a spectral resolution of < 0.05 ppm (1.1 Hz), the highest reported in a portable CMOS-based NMR system, and an imaging resolution of $67\times 67 \times 83\,\, \boldsymbol {\mu }\text{m}^{3}$ .