학술논문
Analysis of cell cycle dynamics using probabilistic cell cycle models
Document Type
Conference
Source
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE. :141-144 Aug, 2011
Subject
Language
ISSN
1557-170X
1094-687X
1558-4615
1094-687X
1558-4615
Abstract
In this study, we develop asynchronous probabilistic cell cycle models to quantitatively assess the effect of ionizing radiation on a human colon cancer cell line. We use both synchronous and asynchronous cell populations and follow treated cells for up to 2 cell cycle times. The model outputs quantify the changes in cell cycle dynamics following ionizing radiation treatment, principally in the duration of both Gi and G 2 /M phases.