부산대학교 도서관

The dimerization partner, RB-like, E2F, and multi-vulval class B (DREAM) complex is an evolutionarily conserved cell-cyclerepressive multiprotein complex and acts as a master coordinator of cell quiescence [1]. Once the DREAM complex is formed, this complex locates to the promoters of nearly a thousand cell-cycle-related genes, repressing their transcription and inducing cell quiescence. In a recent study, I reported that PAF (PCLAF/ KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex [2]. These results unveil one of the fundamental mechanisms of how the cancer cell bypasses cell quiescence during tumorigenesis. I am extending my research focus on DREAM-mediated cancer cell quiescence to microquiescence cancers that are closely related to cancer recurrence and metastasis.