학술논문
Imaging cellular calcium dysfunction in the heart using multi-modal optical mapping
Document Type
Conference
Source
2006 International Conference of the IEEE Engineering in Medicine and Biology Society Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE. :571-575 Aug, 2006
Subject
Language
ISSN
1557-170X
Abstract
To study calcium mediated arrhythmogenesis, we have developed a multi-modal optical mapping system that is able to perform dual calcium voltage and ratiometric calcium optical mapping in the same cardiac preparation. To ensure physiological stability of the preparation, the ECG, coronary pressure, coronary flow, and perfusion temperature are continuously monitored throughout each experiment. The multi-modal optical mapping system has been designed so that it can be easily switched from ratiometric calcium mode to dual calcium-voltage mode. It is concluded that multi-modal optical mapping is a very powerful technique for investigating calcium mediated arrhythmogenesis.