학술논문
Neuromedicator - a disposable drug delivery system with silicon microprobes for neural research
Document Type
Conference
Source
2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS) Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on. :983-986 Jan, 2010
Subject
Language
ISSN
1084-6999
Abstract
We report on a novel disposable drug delivery system for neural research which allows to infuse 16 discrete liquid portions of 0.25 µL directly into neural cell tissue. The system comprises an 11×14.5×3 mm 3 fluidic chip with a pluggable electrical micro connector and two 8-mm-long micromachined silicon fluidic microprobes with a cross-sectional area of 250×250 µm 2 . A pearl chain-like fluidic structure with spherical segments was developed which stores and predefines the required drug liquid portions for the whole time of operation. The micropump principle for liquid delivery is based on the local, irreversible thermal expansion of microspheres embedded into polydimethylsiloxane (PDMS).