학술논문

Toward quantitative X-ray CT phantoms of metastatic tumors using rapid prototyping technology
Document Type
Conference
Source
2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on. :1770-1773 Mar, 2011
Subject
Bioengineering
Communication, Networking and Broadcast Technologies
Computing and Processing
Signal Processing and Analysis
Robotics and Control Systems
Computed tomography
Three dimensional displays
Solid modeling
Tumors
Phantoms
Printing
Tomographic imaging
Computational imaging
X-ray imaging
Three-dimensional image acquisition
Language
ISSN
1945-7928
1945-8452
Abstract
We are seeking ground-truth 3D X-ray CT phantoms with gradations of Hounsfield units that are indistinguishable from scans of human subjects. We modified a 3D printer, a ZCorp Spectrum 510, adding an iodine-based contrast agent, and printed physical models using a powder which consists mainly of cellulose and cornstarch. We scanned these 3D models with a Siemens Somatom Definition AS 128-slice CT scanner. By adjusting the level of iodine within the model, we are able to achieve Hounsfield units as high as 1056, mimicking bone, and as low as −450, similar to pulmonary tissue. We demonstrate how to generate grayscale images within a 3D model that can be imaged using a CT scanner. Unlike solid tumor phantoms, these models can accurately mimic lesions with indistinct boundaries similar to metastatic disease. Our intent is to evaluate the accuracy of computer aided diagnosis systems.