학술논문
Analytical model of extracellular potentials in a tissue slab with a finite bath
Document Type
Periodical
Author
Source
IEEE Transactions on Biomedical Engineering IEEE Trans. Biomed. Eng. Biomedical Engineering, IEEE Transactions on. 52(2):334-338 Feb, 2005
Subject
Language
ISSN
0018-9294
1558-2531
1558-2531
Abstract
Extracellular potentials are often used to assess the activation and repolarization of transmembrane action potentials in cardiac tissue under a variety of experimental conditions. An analytical model of the extracellular potentials arising from a planar wavefront propagating in a three-dimensional slab of cardiac tissue with a variably thick adjacent volume conductor or bath is presented. Starting with the transmembrane potential, the model yields the extracellular potentials at various points in the bath and inside tissue. The results show that the analytical model produces signal timecourses with trivial computational costs that are similar to those computed from a full reaction-diffusion bidomain model with different bath thicknesses for tissue with uniform properties and for tissue with an abrupt ionic inhomogeneity.