학술논문
System identification of hunchback protein patterning in early drosophila embryogenesis
Document Type
Conference
Author
Source
Proceedings of the 48h IEEE Conference on Decision and Control (CDC) held jointly with 2009 28th Chinese Control Conference Decision and Control, 2009 held jointly with the 2009 28th Chinese Control Conference. CDC/CCC 2009. Proceedings of the 48th IEEE Conference on. :7723-7728 Dec, 2009
Subject
Language
ISSN
0191-2216
Abstract
Early patterning in the Drosophila melanogaster embryo occurs through a complicated network of interactions involving transcription factor proteins and the mRNA of their target genes. One such system is the pattern of hunchback mRNA and its regulation by Bicoid and Krüppel proteins. This system is well-studied, but there is disagreement amongst biologists on how exactly hunchback expression is regulated. We attempt here to provide evidence to distinguish between two models in contention, through system identification. Our general approach is to do nonlinear regression on a parametric, nonlinear partial differential equation model which incorporates transcription, diffusion, and degradation. We perform the regression, analyze the results and then interpret the results in the biological context. We also compare our results to previous work on this system.