학술논문

CSSTag: Optical Nanoscale Radar and Particle Tracking for In-Body and Microfluidic Systems With Vibrating Graphene and Resonance Energy Transfer
Document Type
Periodical
Source
IEEE Transactions on NanoBioscience IEEE Trans.on Nanobioscience NanoBioscience, IEEE Transactions on. 16(8):905-916 Dec, 2017
Subject
Bioengineering
Components, Circuits, Devices and Systems
Radar tracking
Nanoscale devices
Optical imaging
Microfluidics
Biomedical optical imaging
High-speed optical techniques
Graphene
Acousto-optic modulator
graphene resonator
multiple particle tracking
nanoscale tagging radar
vibrating Förster resonance energy transfer
microfluidic system
Language
ISSN
1536-1241
1558-2639
Abstract
Biological particle tracking systems monitor cellular processes or particle behaviors with the great accuracy. The emissions of fluorescent molecules or direct images of particles are captured with cameras or photodetectors. The current imaging systems have challenges in detection, collection, and analysis of imaging data, penetration depth, and complicated set-ups. In this paper, a signaling-based nanoscale acousto-optic radar and microfluidic multiple particle tracking (MPT) system is proposed based on the theoretical design providing nanoscale optical modulator with vibrating Förster resonance energy transfer and vibrating cadmium selenide/zinc sulfide quantum dots (QDs) on graphene resonators. The modulator combines significant advantages of graphene membranes having wideband resonance frequencies with QDs having broad absorption spectrum and tunable properties. The solution denoted by chirp spread spectrum(CSS) Tag utilizes classical radar target tracking approaches in nanoscale environments based on the capability to generate CSS sequences identifying different bio-particles. Monte Carlo simulations show significant performance for MPT with a modulator of $10~\mu \text {m} \times 10~\mu \text {m} \times 10~\mu \text{m}$ dimension and several picograms of weight, the signal-to-noise ratio in the range from −7 to 10 dB, simple light emitting diode sources with power less than 4 W/cm 2 and high speed tracking for microfluidic environments.