부산대학교 도서관

Recent studies have reported that transcutaneous spinal stimulation (tSCS) may facilitate improved upper limb motor function in those with incomplete tetraplesia. However, little is known about how tSCS engages upper limb motor pools. This study aimed to explore the extent to which discrete upper limb motor pools can be selectively engaged via altering stimulus location and intensity. 14 participants with intact nervous systems completed two test visits, during which posterior root-muscle reflexes (PRMR) were evoked via a 3x3 cathode matrix applied over the cervicothoracic spine. An incremental recruitment curve at C7 vertebral level was initially performed to attain minimal threshold intensity (MTI) in each muscle. Paired pulses (1ms square monophasic with inter-pulse interval of 50ms) were subsequently delivered at a frequency of 0.25Hz at two intensities (MTI and $\text{MTI}+20\%$) across all nine locations. in a random order. Evoked response to the 1 st (PRMR 1 ) and 2 nd (PRMR2) stimuli were recorded from four upper limb muscles. A significant effect of spinal level was observed in all muscles for PRMR 1 with greater responses recorded more caudally. Unexpectedly, contralateral cathode placement significantly increased PRMR 1 in Biceps Brachii $(\mathrm{P}=0.012)$, Flexor Carpi Radialis $(\mathrm{P}=0.035)$ and Abductor Pollicis Brevis $(\mathrm{P}=0.001)$. Post-activation depression (PAD) was also significantly increased with contralateral cathode placement in Biceps Brachii $(\mathrm{P}=0.001)$, Triceps Brachii $(\mathrm{P}=0.012)$ and Flexor Carpi Radialis $(\mathrm{P}=0.001)$. These results suggest that some level of unilateral motor pool selectivity may be attained via altering stimulus intensity and location during cervicothoracic tSCS.