학술논문
Compensatory Brain Connection Discovery in Alzheimer's Disease
Document Type
Conference
Author
Source
2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) Biomedical Imaging (ISBI), 2020 IEEE 17th International Symposium on. :283-287 Apr, 2020
Subject
Language
ISSN
1945-8452
Abstract
Identification of the specific brain networks that are vulnerable or resilient in neurodegenerative diseases can help to better understand the disease effects and derive new connectomic imaging biomarkers. In this work, we use brain connectivity to find pairs of structural connections that are negatively correlated with each other across Alzheimer's disease (AD) and healthy populations. Such anti-correlated brain connections can be informative for identification of compensatory neuronal pathways and the mechanism of brain networks' resilience to AD. We find significantly anti-correlated connections in a public diffusion-MRI database, and then validate the results on other databases.