학술논문
Monitoring of Microfluidics Systems for PET Radiopharmaceutical Synthesis Using Integrated Silicon Photomultipliers
Document Type
Periodical
Author
Source
IEEE Sensors Journal IEEE Sensors J. Sensors Journal, IEEE. 19(17):7702-7707 Sep, 2019
Subject
Language
ISSN
1530-437X
1558-1748
2379-9153
1558-1748
2379-9153
Abstract
Silicon photomultipliers (SiPM) can be used to sense the position and movement of the radioactive reagents involved in the synthesis of radiopharmaceuticals, while providing information on the evolution through the different steps of this synthesis. An SiPM array can be placed next to a lab-on-chip substrate made of PDMS and is able to detect particles emitted by 18 F, the radioisotope used in fluorine-based positron-emission tomography (PET) imaging. In this paper, an array of 16 SiPM sensors is used to monitor the synthesis of [ 18 F]-based radiopharmaceuticals. Results prove that it is possible to measure the position of the radioactive sample with adequate spatial and temporal resolution.