학술논문
Integrated optical Mach-Zehnder biosensor
Document Type
Periodical
Source
Journal of Lightwave Technology J. Lightwave Technol. Lightwave Technology, Journal of. 16(4):583-592 Apr, 1998
Subject
Language
ISSN
0733-8724
1558-2213
1558-2213
Abstract
We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer (MZI). The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin-based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm/sup 2/.