학술논문
The matter of clinical sequencing for familial breast cancer: The route from Sanger to next generation
Document Type
Conference
Source
2017 E-Health and Bioengineering Conference (EHB) E-Health and Bioengineering Conference (EHB), 2017. :181-184 Jun, 2017
Subject
Language
Abstract
We mentioned the importance of clinical sequence analysis in risk determination, diagnostic and therapeutic process of familial breast cancer and we also summarized next generation sequencing applications in this cancer type. In conclusion, BRCA1/2 genes mutations are associated with an increasing the risk of particularly familial breast cancer. However, sequencing of moderate penetrance genes and/or whole exome could also fill large knowledge gaps in explaining genetic predisposition of breast cancer.