학술논문

A 2D smart pixel detector for time resolved protein crystallography
Document Type
Periodical
Source
IEEE Transactions on Nuclear Science IEEE Trans. Nucl. Sci. Nuclear Science, IEEE Transactions on. 43(3):1243-1247 Jun, 1996
Subject
Nuclear Engineering
Bioengineering
Smart pixels
Proteins
Crystallography
Biology
Materials science and technology
Evolution (biology)
X-ray detection
X-ray detectors
Assembly
Bonding processes
Language
ISSN
0018-9499
1558-1578
Abstract
A smart pixel detector is being developed for Time Resolved Crystallography for biological and material science applications. Using the Pixel Detector presented here, the Laue method will enable the study of the evolution of structural changes that occur within the protein as a function of time. The X-ray pixellated detector is assembled to the integrated circuit through a bump bonding process. Within a pixel size of 150/spl times/150 /spl mu/m/sup 2/, a low noise preamplifier-shaper, a discriminator, a 3 bit counter and the readout logic are integrated. The read out, based on the Column Architecture principle, will accept hit rates above 5/spl times/10/sup 8//cm/sup 2//s with a maximum hit rate per pixel of 1 MHz. This detector will allow time resolved Laue crystallography to be performed in a frameless operation mode, without dead time. Target specifications, architecture and preliminary results on the 8/spl times/8 front-end prototype and the column readout are presented.