학술논문
An image based system biology approach for Alzheimer's disease pathway analysis
Document Type
Conference
Author
Source
2009 IEEE/NIH Life Science Systems and Applications Workshop Life Science Systems and Applications Workshop, 2009. LiSSA 2009. IEEE/NIH. :128-132 Apr, 2009
Subject
Language
Abstract
We report multifactorial analysis of candidate mechanisms of Alzheimer's disease utilizing high content analysis, gene expression microarray, and linear regression model to integrate neuronal imaging data with hippocampal gene expression data. Our analysis led to the identification of several genes that may contribute to different image traits or phenotypes in the amyloid-beta (Aβ) injured neurons. Gene network and biological pathways analysis for those genes were further analyzed and led to several novel pathways that may contribute to amyloid plaque triggered neurite loss.