학술논문
Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis
Document Type
article
Author
Source
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by distribution over gene regions and location in relation to CpG islands. The replicated CpGs were further characterized by involvement in biological pathways to study their functional implications in aging. We identified 67,604 age-associated CpG sites reaching genome-wide significance of FWER