학술논문
Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies-A prospective study.
Document Type
article
Author
Source
PLoS ONE, Vol 13, Iss 5, p e0197148 (2018)
Subject
Language
English
ISSN
1932-6203
Abstract
The study was designed to determine the associations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginines plasma concentrations with all-cause mortality in patients with hematological malignancies. 33 patients with acute myeloid leukemia (AML), 31 patients with non-Hodgkin's lymphoma (nHL), 32 patients with chronic lymphocytic leukemia (CLL) and 48 patients without malignancy were enrolled into the study. Each patient was followed until death or for at least 14.5 months (range: 14.5-53). Median ADMA and SDMA were significantly elevated in AML, nHL and CLL compared to controls (ADMA: 1.36, 1.24, 1.03, 0.55 μmol/l respectively, p