학술논문
Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
Document Type
article
Author
Alexander Arthur Wurm; Polina Zjablovskaja; Miroslava Kardosova; Dennis Gerloff; Daniela Bräuer-Hartmann; Christiane Katzerke; Jens-Uwe Hartmann; Touati Benoukraf; Stephan Fricke; Nadja Hilger; Anne-Marie Müller; Marius Bill; Sebastian Schwind; Daniel G. Tenen; Dietger Niederwieser; Meritxell Alberich-Jorda; Gerhard Behre
Source
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
C/EBPα is a critical transcription factor involved in myelopoiesis and its inactivation is associated with acute myeloid leukemia (AML). Here the authors show a negative feedback loop between C/EBPα and miR-182 and identify this miRNA as a marker of high-risk AML.