학술논문
DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
Document Type
article
Author
Giulia Favaro; Vanina Romanello; Tatiana Varanita; Maria Andrea Desbats; Valeria Morbidoni; Caterina Tezze; Mattia Albiero; Marta Canato; Gaia Gherardi; Diego De Stefani; Cristina Mammucari; Bert Blaauw; Simona Boncompagni; Feliciano Protasi; Carlo Reggiani; Luca Scorrano; Leonardo Salviati; Marco Sandri
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Muscle loss is associated with altered expression of proteins involved in mitochondrial homeostasis, but whether this is causative remains unclear. Here, the authors show that genetic ablation of the pro-fission protein DRP1 leads to accumulation of abnormal mitochondria that induce muscle atrophy by altering Ca2+ homeostasis and cellular stress responses.