학술논문
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia
Document Type
article
Author
Seung Hyun Lee; Nayoung Kim; Minkyu Kim; Sang-Ho Woo; Inhee Han; Jisu Park; Kyeongdae Kim; Kyu Seong Park; Kibyeong Kim; Dahee Shim; Sang-eun Park; Jing Yu Zhang; Du-Min Go; Dae-Yong Kim; Won Kee Yoon; Seung-Pyo Lee; Jongsuk Chung; Ki-Wook Kim; Jung Hwan Park; Sak Lee; Soo-jin Ann; Sang-Hak Lee; Hyo-Suk Ahn; Seong Cheol Jeong; Tae Kyeong Kim; Goo Taeg Oh; Woong-Yang Park; Hae-Ock Lee; Jae-Hoon Choi
Source
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.