학술논문
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Document Type
article
Author
Laura Garcia Perez; Jan Kempski; Heather M. McGee; Penelope Pelzcar; Theodora Agalioti; Anastasios Giannou; Leonie Konczalla; Leonie Brockmann; Ramez Wahib; Hao Xu; Maria Carolina Amezcua Vesely; Shiwa Soukou; Babett Steglich; Tanja Bedke; Carolin Manthey; Oliver Seiz; Björn-Philipp Diercks; Stylianos Gnafakis; Andreas H. Guse; Daniel Perez; Jakob R. Izbicki; Nicola Gagliani; Richard A. Flavell; Samuel Huber
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.