학술논문
Development of a skin- and neuro-attenuated live vaccine for varicella
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Current varicella vaccines retain neurovirulence and can establish latency and reactivate. Here, the authors present preclinical results of a rationally-designed, skin- and neuro-attenuated varicella vaccine candidate, v7D, showing its attenuation in human skin and neuronal cells and its immunogenicity in small animal models and nonhuman primates