학술논문
Prognostic Impact of Coronary Flow Reserve in Patients With Reduced Left Ventricular Ejection Fraction
Document Type
article
Author
Hyun Sung Joh; Doosup Shin; Joo Myung Lee; Seung Hun Lee; David Hong; Ki Hong Choi; Doyeon Hwang; Coen K. M. Boerhout; Guus A. de Waard; Ji‐Hyun Jung; Hernan Mejia‐Renteria; Masahiro Hoshino; Mauro Echavarria‐Pinto; Martijn Meuwissen; Hitoshi Matsuo; Maribel Madera‐Cambero; Ashkan Eftekhari; Mohamed A. Effat; Tadashi Murai; Koen Marques; Joon‐Hyung Doh; Evald H. Christiansen; Rupak Banerjee; Hyun Kuk Kim; Chang‐Wook Nam; Giampaolo Niccoli; Masafumi Nakayama; Nobuhiro Tanaka; Eun‐Seok Shin; Steven A. J. Chamuleau; Niels van Royen; Paul Knaapen; Bon Kwon Koo; Tsunekazu Kakuta; Javier Escaned; Jan J. Piek; Tim P. van de Hoef
Source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 15 (2022)
Subject
Language
English
ISSN
2047-9980
Abstract
Background Intracoronary physiologic indexes such as coronary flow reserve (CFR) and left ventricular ejection fraction (LVEF) have been regarded as prognostic indicators in patients with coronary artery disease. The current study evaluated the association between intracoronary physiologic indexes and LVEF and their differential prognostic implications in patients with coronary artery disease. Methods and Results A total of 1889 patients with 2492 vessels with available CFR and LVEF were selected from an international multicenter prospective registry. Baseline physiologic indexes were measured by thermodilution or Doppler methods and LVEF was recorded at the index procedure. The primary outcome was target vessel failure, which was a composite of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization over 5 years of follow‐up. Patients with reduced LVEF