학술논문
Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 resulting in tumour-promoting epigenetic modifications.