학술논문
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Document Type
article
Author
Tuomas O. Kilpeläinen; Jayne F. Martin Carli; Alicja A. Skowronski; Qi Sun; Jennifer Kriebel; Mary F Feitosa; Åsa K. Hedman; Alexander W. Drong; James E. Hayes; Jinghua Zhao; Tune H. Pers; Ursula Schick; Niels Grarup; Zoltán Kutalik; Stella Trompet; Massimo Mangino; Kati Kristiansson; Marian Beekman; Leo-Pekka Lyytikäinen; Joel Eriksson; Peter Henneman; Jari Lahti; Toshiko Tanaka; Jian’an Luan; Fabiola Del Greco M; Dorota Pasko; Frida Renström; Sara M. Willems; Anubha Mahajan; Lynda M. Rose; Xiuqing Guo; Yongmei Liu; Marcus E. Kleber; Louis Pérusse; Tom Gaunt; Tarunveer S. Ahluwalia; Yun Ju Sung; Yolande F. Ramos; Najaf Amin; Antoinette Amuzu; Inês Barroso; Claire Bellis; John Blangero; Brendan M. Buckley; Stefan Böhringer; Yii-Der I Chen; Anton J. N. de Craen; David R. Crosslin; Caroline E. Dale; Zari Dastani; Felix R. Day; Joris Deelen; Graciela E. Delgado; Ayse Demirkan; Francis M. Finucane; Ian Ford; Melissa E. Garcia; Christian Gieger; Stefan Gustafsson; Göran Hallmans; Susan E. Hankinson; Aki S Havulinna; Christian Herder; Dena Hernandez; Andrew A. Hicks; David J. Hunter; Thomas Illig; Erik Ingelsson; Andreea Ioan-Facsinay; John-Olov Jansson; Nancy S. Jenny; Marit E. Jørgensen; Torben Jørgensen; Magnus Karlsson; Wolfgang Koenig; Peter Kraft; Joanneke Kwekkeboom; Tiina Laatikainen; Karl-Heinz Ladwig; Charles A. LeDuc; Gordon Lowe; Yingchang Lu; Pedro Marques-Vidal; Christa Meisinger; Cristina Menni; Andrew P. Morris; Richard H. Myers; Satu Männistö; Mike A. Nalls; Lavinia Paternoster; Annette Peters; Aruna D. Pradhan; Tuomo Rankinen; Laura J. Rasmussen-Torvik; Wolfgang Rathmann; Treva K. Rice; J Brent Richards; Paul M. Ridker; Naveed Sattar; David B. Savage; Stefan Söderberg; Nicholas J. Timpson; Liesbeth Vandenput; Diana van Heemst; Hae-Won Uh; Marie-Claude Vohl; Mark Walker; Heinz-Erich Wichmann; Elisabeth Widén; Andrew R. Wood; Jie Yao; Tanja Zeller; Yiying Zhang; Ingrid Meulenbelt; Margreet Kloppenburg; Arne Astrup; Thorkild I. A. Sørensen; Mark A. Sarzynski; D. C. Rao; Pekka Jousilahti; Erkki Vartiainen; Albert Hofman; Fernando Rivadeneira; André G. Uitterlinden; Eero Kajantie; Clive Osmond; Aarno Palotie; Johan G. Eriksson; Markku Heliövaara; Paul B. Knekt; Seppo Koskinen; Antti Jula; Markus Perola; Risto K. Huupponen; Jorma S. Viikari; Mika Kähönen; Terho Lehtimäki; Olli T. Raitakari; Dan Mellström; Mattias Lorentzon; Juan P. Casas; Stefanie Bandinelli; Winfried März; Aaron Isaacs; Ko W. van Dijk; Cornelia M. van Duijn; Tamara B. Harris; Claude Bouchard; Matthew A. Allison; Daniel I. Chasman; Claes Ohlsson; Lars Lind; Robert A. Scott; Claudia Langenberg; Nicholas J. Wareham; Luigi Ferrucci; Timothy M. Frayling; Peter P. Pramstaller; Ingrid B. Borecki; Dawn M. Waterworth; Sven Bergmann; Gérard Waeber; Peter Vollenweider; Henrik Vestergaard; Torben Hansen; Oluf Pedersen; Frank B. Hu; P Eline Slagboom; Harald Grallert; Tim D. Spector; J.W. Jukema; Robert J. Klein; Erik E Schadt; Paul W. Franks; Cecilia M. Lindgren; Rudolph L. Leibel; Ruth J. F. Loos
Source
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.