학술논문
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
Document Type
article
Author
Michelle Daya; Nicholas Rafaels; Tonya M. Brunetti; Sameer Chavan; Albert M. Levin; Aniket Shetty; Christopher R. Gignoux; Meher Preethi Boorgula; Genevieve Wojcik; Monica Campbell; Candelaria Vergara; Dara G. Torgerson; Victor E. Ortega; Ayo Doumatey; Henry Richard Johnston; Nathalie Acevedo; Maria Ilma Araujo; Pedro C. Avila; Gillian Belbin; Eugene Bleecker; Carlos Bustamante; Luis Caraballo; Alvaro Cruz; Georgia M. Dunston; Celeste Eng; Mezbah U. Faruque; Trevor S. Ferguson; Camila Figueiredo; Jean G. Ford; Weiniu Gan; Pierre-Antoine Gourraud; Nadia N. Hansel; Ryan D. Hernandez; Edwin Francisco Herrera-Paz; Silvia Jiménez; Eimear E. Kenny; Jennifer Knight-Madden; Rajesh Kumar; Leslie A. Lange; Ethan M. Lange; Antoine Lizee; Pissamai Maul; Trevor Maul; Alvaro Mayorga; Deborah Meyers; Dan L. Nicolae; Timothy D. O’Connor; Ricardo Riccio Oliveira; Christopher O. Olopade; Olufunmilayo Olopade; Zhaohui S. Qin; Charles Rotimi; Nicolas Vince; Harold Watson; Rainford J. Wilks; James G. Wilson; Steven Salzberg; Carole Ober; Esteban G. Burchard; L. Keoki Williams; Terri H. Beaty; Margaret A. Taub; Ingo Ruczinski; Rasika A. Mathias; Kathleen C. Barnes; CAAPA
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.