학술논문
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
Document Type
article
Author
Noam D. Beckmann; Phillip H. Comella; Esther Cheng; Lauren Lepow; Aviva G. Beckmann; Scott R. Tyler; Konstantinos Mouskas; Nicole W. Simons; Gabriel E. Hoffman; Nancy J. Francoeur; Diane Marie Del Valle; Gurpawan Kang; Anh Do; Emily Moya; Lillian Wilkins; Jessica Le Berichel; Christie Chang; Robert Marvin; Sharlene Calorossi; Alona Lansky; Laura Walker; Nancy Yi; Alex Yu; Jonathan Chung; Matthew Hartnett; Melody Eaton; Sandra Hatem; Hajra Jamal; Alara Akyatan; Alexandra Tabachnikova; Lora E. Liharska; Liam Cotter; Brian Fennessy; Akhil Vaid; Guillermo Barturen; Hardik Shah; Ying-chih Wang; Shwetha Hara Sridhar; Juan Soto; Swaroop Bose; Kent Madrid; Ethan Ellis; Elyze Merzier; Konstantinos Vlachos; Nataly Fishman; Manying Tin; Melissa Smith; Hui Xie; Manishkumar Patel; Kai Nie; Kimberly Argueta; Jocelyn Harris; Neha Karekar; Craig Batchelor; Jose Lacunza; Mahlet Yishak; Kevin Tuballes; Ieisha Scott; Arvind Kumar; Suraj Jaladanki; Charuta Agashe; Ryan Thompson; Evan Clark; Bojan Losic; Lauren Peters; The Mount Sinai COVID-19 Biobank Team; Panagiotis Roussos; Jun Zhu; Wenhui Wang; Andrew Kasarskis; Benjamin S. Glicksberg; Girish Nadkarni; Dusan Bogunovic; Cordelia Elaiho; Sandeep Gangadharan; George Ofori-Amanfo; Kasey Alesso-Carra; Kenan Onel; Karen M. Wilson; Carmen Argmann; Supinda Bunyavanich; Marta E. Alarcón-Riquelme; Thomas U. Marron; Adeeb Rahman; Seunghee Kim-Schulze; Sacha Gnjatic; Bruce D. Gelb; Miriam Merad; Robert Sebra; Eric E. Schadt; Alexander W. Charney
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.