학술논문
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Document Type
article
Author
L. Vanderbeke; P. Van Mol; Y. Van Herck; F. De Smet; S. Humblet-Baron; K. Martinod; A. Antoranz; I. Arijs; B. Boeckx; F. M. Bosisio; M. Casaer; D. Dauwe; W. De Wever; C. Dooms; E. Dreesen; A. Emmaneel; J. Filtjens; M. Gouwy; J. Gunst; G. Hermans; S. Jansen; K. Lagrou; A. Liston; N. Lorent; P. Meersseman; T. Mercier; J. Neyts; J. Odent; D. Panovska; P. A. Penttila; E. Pollet; P. Proost; J. Qian; K. Quintelier; J. Raes; S. Rex; Y. Saeys; J. Sprooten; S. Tejpar; D. Testelmans; K. Thevissen; T. Van Buyten; J. Vandenhaute; S. Van Gassen; L. C. Velásquez Pereira; R. Vos; B. Weynand; A. Wilmer; J. Yserbyt; A. D. Garg; P. Matthys; C. Wouters; D. Lambrechts; E. Wauters; J. Wauters
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.