학술논문
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Document Type
article
Author
Thorunn A. Olafsdottir; Fannar Theodors; Kristbjorg Bjarnadottir; Unnur Steina Bjornsdottir; Arna B. Agustsdottir; Olafur A. Stefansson; Erna V. Ivarsdottir; Jon K. Sigurdsson; Stefania Benonisdottir; Gudmundur I. Eyjolfsson; David Gislason; Thorarinn Gislason; Steinunn Guðmundsdóttir; Arnaldur Gylfason; Bjarni V. Halldorsson; Gisli H. Halldorsson; Thorhildur Juliusdottir; Anna M. Kristinsdottir; Dora Ludviksdottir; Bjorn R. Ludviksson; Gisli Masson; Kristjan Norland; Pall T. Onundarson; Isleifur Olafsson; Olof Sigurdardottir; Lilja Stefansdottir; Gardar Sveinbjornsson; Vinicius Tragante; Daniel F. Gudbjartsson; Gudmar Thorleifsson; Patrick Sulem; Unnur Thorsteinsdottir; Gudmundur L. Norddahl; Ingileif Jonsdottir; Kari Stefansson
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8.