학술논문
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Document Type
article
Author
Jeroen Baardman; Sanne G. S. Verberk; Saskia van der Velden; Marion J. J. Gijbels; Cindy P. P. A. van Roomen; Judith C. Sluimer; Jelle Y. Broos; Guillermo R. Griffith; Koen H. M. Prange; Michel van Weeghel; Soufyan Lakbir; Douwe Molenaar; Elisa Meinster; Annette E. Neele; Gijs Kooij; Helga E. de Vries; Esther Lutgens; Kathryn E. Wellen; Menno P. J. de Winther; Jan Van den Bossche
Source
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.