학술논문
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial metabolism is perturbed.